Welcome to HistoCheck - a HLA Sequence Interpreter

Databases

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Histocheck

HistoCheck's databases contain HLA sequences from the HLA Informatics Group when doing compatibility checks. You may view the alleles for the following genes: HLA-A HLA-B HLA-C HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 In addition to the amino acid sequence, calculating the dissimilarity score requires information about the function of each given amino acid i.e. whether it is peptide-binding or in contact with the T-cell receptor. This information has been collected from several sources and can be found in the following tables:

Table 1.	HLA class I residues that contact the antigenic peptide and/ or the TCR	html or word
Table 2.	HLA-DR1 residues of the ß chain that contact the antigenic peptide and/or the TCR	html or word
Table 3.	Risler's Amino Acid Substitution Matrix	html or word

Shared T-Cell Epitope Algorithms for HLA-DPB1

Table 1.

Evidence based [TCE3_EB,TCE4_EB] and Sequence based [TCE4_SB] HLA-DPB1          alleles Classification Table

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References >>>